- Illness with fever and increased need of insulin.
- Change in school or work activities with a new schedule or different physical activity.
- Change in body weight with 5-10 % or more.
- Women may have different insulin needs during different phases of the menstrual cycle.
- Initiation of treatment with drugs that increase the need of insulin (such as cortisone).
- Prolonged physical exercise (12-24 hours duration or more).