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Statins may reduce risk for renal dysfunction in Type 2 diabetes

Use of statins reduces the risk for renal dysfunction in individuals with Type 2 diabetes, report researchers.

“Amongst all diabetes-associated complications, diabetic nephropathy has probably the most detrimental consequences resulting in dialysis and heightened cardiovascular risks.

As high cholesterol has been associated with increased risk of renal disease, Ma and team assessed whether statin treatment reduces the risk for renal dysfunction in patients with Type 2 diabetes.

They recruited a consecutive cohort of 5264 Type 2 diabetics without renal dysfunction between 1996 and 2005, who were followed-up for 4.9 years on average. The participants were aged a median of 55 years with a median disease duration of 6.0 years.

During follow-up, 703 (13.4%) patients developed renal dysfunction, defined as an estimated glomerular filtration rate of less than 60 ml/min/1.73 m2 or hospitalization with a diagnosis of renal disease.

The team found that after controlling for baseline risk factors, the 1275 (22.2%) patients who were treated with statins over the follow-up period were a significant 68% less likely to have developed renal dysfunction that those who were not.

“Despite aggressive control of risk factors such as blood pressure and blood glucose, as well as the use of angiotensin converting enzyme-inhibitors or angiotensin receptor blockers, patients with Type 2 diabetes have large residual risk for progressive deterioration of renal function and end-stage renal disease,” write the authors.

They conclude: “In the absence of large-scale clinical trials with hypothesis defined a priori, our findings concord with previous analysis and provides clinically relevant information to guide clinical practice, especially in ethnic groups at high risk for diabetic renal disease.”

The results of this study are published in the journal Diabetes Research and Clinical Practice.
Source: Diabetes Res Clin Pract 2010; Advance online publication
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